Welcome to the AsthmaMap project, a community-driven effort focused on a comprehensive description of asthma mechanisms and its applications for developing models, data interpretation and hypothesis generation.


AsthmaMap architecture

The AsthmaMap includes three interconnected layers of granularity: Cellular Interactions (CI), a high-level overview; Molecular Relations (MR), the intermediate level of details; Biochemical Mechanisms (BM), the most detailed layer.

AsthmaMap Cellular Interactions AsthmaMap Molecular Relations AsthmaMap Biochemical Mechanisms

Content: cell-to-cell communication, each receptor represents the corresponding pathway of the AF and PD layers.

Format: activity flows.

Purpose: disease overview, defining the content for the detailed maps, disease endotype visualisation.

Compatible databeses: MetaCore Pathway Maps (overview type).

Content: compact representation of signalling events, molecular interactions without details on processes.

Format: activity flows.

Purpose: ‘omics visualisation, network-enrichment analysis, interpretation and hypothesis generation, logical models.

Compatible databeses: MetaCore Pathway Maps, Ingenuity Pathways Knowledge Base, KEGG Pathway Database.

Content: comprehensive detailed maps - integrated detailed metabolic, signalling and gene regulatory pathways.

Format: process descriptions.

Purpose: unambiguous visualisation of molecular processes, the basis for modelling and simulation.

Compatible databases: Reactome Pathway Database, PANTHER Pathways, Recon2 reconstruction of human metabolism.