ILC precursor:extracellular
**ECM remodiling
**Bone destruction
**Osteoclast
differentiation
**Th17 cell
differentiation
IL17A
IL6
IL1B
IL17F
MMP1
MMP9
TNFSF11
MMP3
IL21
IL12B;IL23A
IL33
ILC precursor:membrane
IL17RA
IL17RC
IL23R;IL12RB1
IL1RL1
IL1RAP
ILC precursor:cytosol
**Chemokines and
adhesion
**Chemotaxis
**GM-CSF
signaling
**Granulopoiesis
**IL-6 signaling
pathway
**Inflammatory
response
**PGE2 synthesis
**Prostaglandin
2 biosynthesis
**Transcription
regulation
of granulocyte
development
AKT1;AKT2;
AKT3
GSK3B
DEFB4A;
DEFB4B
**Antibacterial
activity
**Chemotaxis of
CCR6-positive
T cells
**Chemotaxis of
CCR6-positive
dendritic cells
CCL2
CCL7
LCN2
PTGS2
CCL20
TRAF3IP2
IKBKG
MAP3K7
TRAF6
CXCL5
**Neutrophil
chemotaxis
MAPK1;
MAPK3
CHUK;IKBKB
JUN;FOS
CSF3
CXCL6
CSF2
CXCL1
ICAM1
**Cell adhesion
JAK1
JAK2
MAP2K1;MAP2K2
MUC5AC
MUC5B
CXCL8
PIK3R1;PIK3R2;
PIK3R3
*L-Arginine
*L-Citrulline
*NO
MAP2K3
MAPK14;MAPK11;
MAPK13;MAPK12
MAP2K6
NOS2
MAP3K14
*O(,2)
PIK3CB;PIK3CD;
PIK3CA
*PtdIns(3,4,5)P3
*PtdIns(4,5)P2
TNFSF11
**MAPK activation
MAPK10;
MAPK8;
MAPK9
**PTMs in
IL-17-inducced
CIKS-independent
singaling pathway
**PTMs in IL-17-induced
CIKS-independent
singaling pathway
TNIP2
MAP3K8
**Regulation of
gene expression
TRAF2
TRAF5
UBB;UBC
UBE2N
**PTMs in IL-17-induced
CIKS-dependent
NF-kB signaling and
mRNA stabilization
RELA;REL;NFKB1;
RELB;NFKB2
IKBKE
**PTMs in IL-17-induced
CIKS-independent
signaling pathway
MAP3K3
MAP2K4
TAB1
TAB2
UBA1
UBE2V1
**mRNA
stabilization
TRAF4
BTRC;CUL1;
FBXW11;FBXW7;
RBX1;SKP1;SKP2
TRAF3
SRSF1
TBK1
USP25
**PTMs in
IL-17-induced
CIKS-dependent
MAPK signaling pathways
DUSP1
MIR101-2;
MIR101-1
RPS6KA1;
RPS6KA2;
RPS6KA3
JAK3
TYK2
RAF1
STAT2
PDPK1
MAPKAPK2
IL17A
**Expandion and/or
maintenance
the Th17 cell
population
**IL-17 signaling
pathway
IL17F
SOCS3
NFKBIA
SOCS1
**IL-13 signaling
via JAK-STAT
**IL-13 signaling
via PI3K-ERK
**IL-5 signalling
**IL-6 signalling
pathway
**IL-8 dependent
cell migration
and adhesion
**Inhibitory action of
Lipoxins on
pro-inflammatory
TNF-alpha signalling
NOS3
SELE
RPS6KA5
H2AFX;H2AFZ;HIST1H2AC;
HIST1H2AD;HIST1H2AG;
HIST1H2AI;HIST1H2AJ;
HIST1H2AK;HIST1H2AL;
HIST1H2AM;HIST2H2AC
H2BFS;HIST1H2BB;HIST1H2BC;HIST1H2BD;
HIST1H2BE;HIST1H2BF;HIST1H2BG;
HIST1H2BH;HIST1H2BI;HIST1H2BJ;
HIST1H2BL;HIST1H2BM;HIST1H2BN;
HIST1H2BO;HIST2H2BE;LOC102724334
IL13
IL5
IL6
MYD88
IRAK1
IRAK4
MAP2K7
*N-omega-
Hydroxy-
L-arginine
TNF
VCAM1
**Angiogenesis
TMED1
ILC precursor:nucleus
CEBPB
CEBPD
SP1
NFKBIA;NFKBIB;
NFKBIE
RELA;REL;NFKB1;
RELB;NFKB2
ATF2
**Regulation of
gene expression
**Inhibition of
gene expression
ELK1
FOS
JUN
FOSL1
STAT1
STAT3
STAT4
STAT5A;
STAT5B
RORC
IL17A
TNFSF11