AsthmaMap Cellular Interactions 1.2

A new version of the AsthmaMap Cellular Interactions map is being developed in collaboration with the Laboratory for Translational Research and Personalised Medicine at the Moscow Institute of Physics and Technology. Newly introduced changes are marked in red.

Version 1.2.02

Version 1.2.01

What is new in the AsthmaMap Cellular Interactions 1.2

The following tables provide details on the added content in comparison with the released version 1.1.

Endothelial cell

VCAM1, ICAM1PMID 16601240, PMID 10050668
ICAM1PMID 7505008, PMID 7512980
VCAM1PMID 11964048, PMID 17906117

Goblet cell

PGE2 → PTGER2, PTGER4 → MUC5AC, MUC5B, MUC2PMID 12391274, PMID 10198352, PMID 19907312
PGF2-alpha → PTGFR → MUC5ACPMID 19201889
LTC4, LTD4 → CysLTR1 → MUC5ACPMID 10378985
Goblet cell → Mucus hypersecretion in asthma → MUC5AC, MUC5B, MUC2PMID 19077699, PMID 19907312, PMID 11179133, PMID 11943022
IL-13 → Mucus hypersecretion in asthmaPMID 18028464, PMID 12794003, PMID 16980555, PMID 12091879
IL-17 → mucin production in airway epithelial cellsPMID 19841186, PMID 16859642, PMID 12624114

Epithelial cell

IL17R → CXCL8, CXCL1, CXCL5 → neutrophil migrationPMID 14557379, PMID 12591113, PMID 11692108, PMID 11325811, PMID 12034575

Fibroblast

TGF-beta → Extracellular matrix production → FibrosisPMID 15591881, PMID 20591736, PMID 21514131, PMID 17325694, PMID 11451940, PMID 17589920

Eosinophil

CCR3PMID 23334207, PMID 21042920, PMID 14561210
CCR4PMID 21042920, PMID 21208220, PMID 13679815
IL3 → IL3R → Cell survival, IL5 → IL5R → Cell survival, GM-CSF → GM-CSFR → Cell survivalPMID 25563855, PMID 9817161, PMID 1726704, PMID 1864012, PMID 2197048, PMID 9925957, PMID 12358998, PMID 18511250
CCR3 → Cell survivalPMID 12673069
CysLTR1 → Cell survivalPMID 10852761, PMID 12771542
IL33R → Cell survivalPMID 18539196, PMID 18762778
PAF → PTAFR → Eosinophil migration...PMID 17923399, PMID 12141728, PMID 3361129, PMID 8380250, PMID 10579457
LTB4 → LTB4R → Eosinophil migration…PMID 12141728, PMID 9870930
Histamine → HRH4 → Eosinophil migration…PMID 23334207, PMID 15131002, PMID 450, PMID 14530216, PMID 17275092, PMID 18172439, PMID 21741967
LTD4, LTE4 → CysLTR1 → Eosinophil migration…PMID 11994100, PMID 12373000, PMID 16364169, PMID 12771542
PGD2 → PTGDR2 → Eosinophil migration…PMID 23334207, PMID 23525348, PMID 11208866, PMID 18691063
CCR3 → ROS productionPMID 10761311, PMID 12797483, PMID 9692884, PMID 8874220
GM-CSFR, IL5R, IL3R → ROS productionPMID 8482914, PMID 2826636, PMID 1647680
IL33R → ROS productionPMID 18539196
PTAFR → ROS productionPMID 8874220, PMID 7946388, PMID 1659593, PMID 1321621, PMID 16162268, PMID 7636306
PTGDR2 → ROS productionPMID 17714552, PMID 20559016
GM-CSFR, IL5R, IL3R → Lipid metabolismPMID 9766638, PMID 1647680, PMID 19416659, PMID 10384149
CCR3 → Lipid metabolismPMID 11274187, PMID 15947420
PTAFR → Lipid metabolismPMID 9294145, PMID 9766638, PMID 3118415, PMID 3774850, PMID 10224472, PMID 19416659
PTGDR, PTGDR2 → Lipid metabolismPMID 22102725, PMID 20973774, PMID 16424158

Neutrophil

CXCL8 → CXCR1, Neutrophil PMID 8692878
CXCL8 → CXCR1, Neutrophil PMID 19564575
LTB4 → LTB4R → ROS productionPMID 22884975, PMID 21424583, PMID 16006535, PMID 6327816, PMID 2544983
LTB4 → LTB4R → ROS production → Cell survivalPMID 22884975, PMID 20685738
IgE → LGALS3 (Galectin-3) → ROS productionPMID 8030995, PMID 8418206, PMID 8676078, PMID 12442951
IgE → ROS productionPMID 16624933
IgE → FcɛR1 → Lipid metabolismPMID 19862934, PMID 17412406
IgE → ROS production → Lipid metabolism PMID 16624933, PMID 17606988, PMID 8391372
IgE → FcɛR1 → FcɛR1-induced gene expression → CXCL8PMID 11292654, PMID 15178703, PMID 19862934
CXCR1, CXCR2 → Neutrophil migration to lung compartmentPMID 21839682, PMID 16433851, PMID 17986378, PMID 22627375, PMID 15569498, PMID 18779195, PMID 11959064, PMID 15637552, PMID 17412406, PMID 17471178, PMID 20685738
LTB4R → Neutrophil migration to lung compartmentPMID 12562556, PMID 16433851, PMID 10977867, PMID 1952580, PMID 8108534, PMID 8386926, PMID 8994512, PMID 16126787, PMID 21352897, PMID 21421908, PMID 20685738

Airway smooth muscle

CYSLTR1 → Smooth muscle contractionPMID 16183910
TXA2 → TBXA2R → Smooth muscle contractionPMID 8620702 (in asthma), PMID 8391372 (in asthma), PMID 14751539 (Thromboxane A2 review), PMID 18374420 (Thromboxane A2 review), PMID 22064668 (Thromboxane A2 review)
TBXA2R, HRH1 → Smooth muscle cell proliferationPMID 16723377
TBXA2R → Smooth muscle cell proliferationPMID 16723377, PMID 14751539, PMID 7591017


The changes cover in part the following suggestions from Richard Knowles: #1, #2, #3, #4, #11, #12.