What Are the Side Effects of Quinine in Tonic Water?

Medically Reviewed on 10/7/2022
What Are the Side Effects of Quinine in Tonic Water
Side effects of quinine in tonic water may include nausea, vomiting, diarrhea, and stomach cramps

Quinine in tonic water is allowed in quantities of no more than 83 parts per million (ppm) according to the FDA. Although consuming tonic water in moderation is unlikely to cause negative effects, some people may experience side effects if they consume too much or are extremely sensitive to quinine. 

Side effects of quinine may include:

What is quinine and what is it used for?

Quinine is taken from the bark of the Cinchona tree and has a bitter flavor. The tree is indigenous to central and south America, Western Africa, and the Caribbean.

Quinine was initially developed as a malaria treatment in the 1800s. It is still occasionally used today, although malaria parasites have developed some resistance to it and other medications have become available.

Comparatively, the amount of quinine in half a liter of tonic water (assumed to contain 83 ppm quinine) is equal to roughly 41.5 mg. However, malaria treatments typically contain about 540 mg or more and are administered 3 times a day.

Quinine has also been used as a remedy for leg cramps. However, this is no longer advised due to concerns about its efficacy and safety. The FDA has prohibited the over-the-counter sale of quinine because it has the potential to be misused, is not always effective, and can have negative side effects.

Who should avoid quinine?

Quinine in tonic water should be avoided if you are taking the following medications because they may interact with each other:

If you decide to take quinine as a medication, make sure to carefully follow the dosage instructions and never take it without a prescription. 

People with the following conditions should avoid quinine in medications:

For people with these medical conditions, the amount of quinine in tonic water is unlikely to interfere with their prescription or cause problems. However, supplements or medications containing quinine should be avoided.

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Medically Reviewed on 10/7/2022
References
Image Source: iStock image

Drugs and Supplements Quinine (Oral Route): https://www.mayoclinic.org/drugssupplements/quinine-oral-route/side-effects/drg-20065753?p=1#:~:text=Serious%20skin%20reactions%20can%20occur,hypoglycemia%20(low%20blood%20sugar).

Disseminated Intravascular Coagulation Due to Drinking Tonic Water: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765093/

Quinine: https://medlineplus.gov/druginfo/meds/a682322.html